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PUBLICATIONS

2018

180. Anup Paul, Surendra Kumar, Anubhav Raj, A. A. Sonkar, Sudha Jain, Atin Singhai and Raja Roy (2018). Alteration in lipid composition differentiates breast cancer tissues: A 1H HRMAS NMR metabolomic study. Metabolomics, DOI: 10.1007/s11306-018-1411-3.

 

179. TushaTripathia,, Anil Bhatiaa, Suruchi Singh, Kunwar Sarvendra, Abdul Rahman Khan, Om P. Sidhu and Raja Roy (2018). Metabolite Profiling of Commiphora wightii (Guggul) with Respect to Seasons. Nat.Prod.Comm.13, 1.

 

178. Anil Bhatia, Tusha Tripathi, Suruchi Singh, Hema Bisht, H M. Behl, Raja Roy and O. P. Sidhu (2018). Comprehensive metabolite profiling in distinct chemotypes of Commiphora wightii. Natural Product Research doi.org/10.1080/14786419.2018.1431629.

 

177. G. Nagesh Babu, Manjeet Gupta, Vimal K. Paliwal, Suruchi Singh, Tanushri Chatterji and Raja Roy (2018) Serum metabolomics study in a group of Parkinson's disease patients from northern India. Clinica Chimica Acta. 480, 214.

176. Alka Singh, Rajeshwar Nath Srivastava, Ashok Agrahari, Suruchi Singh, Saloni Raj, Tanushri Chatterji, Abbas Ali Mahdi, Ravindra Kumar Garg and Raja Roy (2018). Proton NMR based serum metabolic profile correlates with the neurological recovery in treated acute spinal cord injury (ASCI) subjects: A pilot study. Clinica Chimica Acta. 480, 150.

175. AbdulHamid Emwas, Edoardo Saccenti,  Xin Gao, Ryan T. McKay, Vitor A. P. Martins dos Santos, Raja Roy and David S. Wishart (2018). Recommended strategies for spectral processing and post-processing of 1D 1H-NMR data of biofluids with a particular focus on urine. Metabolomics. DOI: 10.1007/s11306-018-1321-4.

174. Rohit Khanna, Kapila Kumar and Raja Roy (2018). A case study of primary malignancy of buccal mucosa using proton HR-MAS NMR spectroscopy on tissue specimens. Journal of Oral Biology and Craniofacial Research. 8, 68.

2017

173. Neeraj Rastogi, Nidhi Tyagi, Ovender Singh, B. S. Hemanth Kumar, Udai P. Singh, Kaushik Ghosh and Raja Roy (2017). Mn(II) based T1 and T2 potential MRI  contrast agent appended with tryptamine: Recognition moiety for Aβ-plaques. Journal. Inorg. Biochem. 177, 76.

172. Manvendra Pratap Singh, Mona Saxena, C.S. Saimbi, Jamal M Arif and Raja Roy (2017), Metabolic profiling by 1H NMR spectroscopy of saliva shows clear distinction between control and diseased case of periodontitis. Metabolomics. DOI: 10.1007/s11306-017-1245-4 (in press).

171. Tanushri Chatterji, Suruchi Singh, Manodeep Sen, A.K. Singh, G.R. Agarwal, D.K. Singh, J.K. Srivastava, A Singh, R.N. Srivastava and Raja Roy (2017), Proton NMR metabolic profiling of CSF reveals distinct differentiation of meningitis from negative controls. Clinica Chimica Acta. 469, 42.

170. Anil Bhatia, Baleshwar Meena, Sanjeev K. Shukla, Om P. Sidhu, Dalip K. Upreti, Anuradha Mishra, Raja Roy & Chandra Shekhar Nautiyal (2017). Determination of Pentacyclic Triterpenes from Betula utilis by High-Performance Liquid Chromatography and High Resolution Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopy. Analytical Letters. 50, 233.

2016

169. Suruchi Singh and Raja Roy (2016), The Application of Absolute Quantitative 1H NMR Spectroscopy in Drug Discovery and Development. Expert Opinion On Drug Discovery. 11, 695.

168. Tanushri Chatterji, Suruchi Singh, Manodeep Sen, Ajai Kumar Singh, Pradeep Kumar Maurya, Nuzhat Husain, Janmejai Kumar Srivastava, Sudhir Kumar Mandal and Raja Roy (2016), Comprehensive 1H NMR metabolic profiling of body fluids for differentiation of meningitis in adults. Metabolomics. 12, 130.

167. Abdul-Hamid Emwas, Raja Roy, Ryan T. McKay, Danielle Ryan, Lorraine Brennan, Leonardo Tenori, Claudio Luchinat, Xin Gao, Ana Carolina Zeri, G. A. Nagana Gowda, Daniel Raftery, Christoph Steinbeck, Reza M Salek and David S. Wishart (2016). Recommendations and Standardization of Biomarker Quantification Using NMR-based Metabolomics with Particular Focus on Urinary Analysis. J.Proteome.Res. 15, 360.

166. Suruchi Singh, Tanushri Chatterji, Manodeep Sen, Ishwar Ram Dhayal, Swati Mishra, Nuzhat Husain, Apul Goel and Raja Roy (2016). Serum procalcitonin levels in combination with 1H NMR spectroscopy: A rapid indicator for differentiation of urosepsis. Clinica Chimica Acta. 453, 205.

2015

165. Anil Bhatia, S.K.Bharti, Tusha Tripathi, Anuradha Mishra, Om P. Sidhu, Raja Roy and C.S. Nautiyal (2015). Metabolic profiling of Commiphora wightii (Guggul) reveals a potential source for pharmaceuticals and nutraceuticals. Phytochemistry. 110, 29.

164. Surender Kumar, Shailendra Kumar, Raja Roy, A.S.Rathore, M.M.Goel, Gaurav Agarwal and Sandeep Kumar (2015). High Resolution Magic Angle Proton Magnetic Resonance Spectroscopy (HRMAS) in Intact Sentinel Node Biopsy from Breast Cancer Patients: A New Diagnostic Tool!. Journal of Surgery. 10, 227.

 

163. Vibhor V. Borkar,  Ujjal Poddar, Niraj Kumari, Suruchi Singh, Raja Roy and  Surender K. Yachha (2015). Duodenal Morphometry and Small Bowel Permeability in Children with Portal Hypertension. J. Pedia. Gastroent. and Nutrition. 60, 171.

 

162. Abdul-Hamid Emwas, Claudio Luchinat, Paola Turano, Leonardo Tenori, Raja Roy, Reza M. Salek, Danielle Ryan, Jasmeen S. Merzaban, Rima Kaddurah-Daouk,  Ana Carolina Zeri,  G. A. Nagana Gowda, Daniel Raftery, Yulan Wang, Lorraine Brennan and David S. Wishart (2015). Standardizing the experimental conditions for using urine in NMR-based metabolomic studies with a particular focus on diagnostic studies: a review. Metabolomics. 11, 872.

2014

 

161. S.K.Bharti and Raja Roy (2014). Metabolites Identification in NMR-based Metabolomics. Current Metabolomics. 2, 163.

 

160. Suruchi Singh, Shatakshi Srivastava, Raja Roy, K. Gaurav, S. Kumar, Abhinav A Sonkar, M.M. Goel and R. Garg (2014). Metabolic profiling of cervical tubercular lymphadenitis tissues by proton HR-MAS NMR spectroscopy. Metabolomics, 10, 975.

 

159. D.V.Singh, S.K.Bharti, Shikha Agarwal, Raja Roy and Krishna Mishra (2014). Study of interaction of human serum albumin with curcumin by NMR and docking. J. Mol. Model. 20, 1.

158. P.Rana, M.Gupta, A.R.Khan, B.S.Hemant Kumar, Raja Roy and S.Khushu (2014), NMR based metabolomics reveals acute hippocampal metabolic fluctuations during cranial irradiation in murine model. Neurochem. Int. 74, 1.

 

157. R. Tyagi, P. Rana, M. Gupta, D. Bhatnagar, S. Srivastava, Raja Roy and S. Khushu (2014), 1H NMR spectroscopic analysis detects metabolic disturbances in rat urine on acute exposure to heavy metal tungsten alloy based metals salt. Chem. Biol. Interact. 211, 20.

 

2013

156. Ajesh Goyal, U.C.Ghoshal, Imran Ahmad, Raja Roy, Deepakshi Srivastava, Samir Mohindra, V.A.Saraswat, C.L.Khetrapal (2013), Frequency and factors associated with increased small intestinal permeability in patients with portal hypertension. Tropical Gastroenterology. 34, 136.

 

155. Shatakshi Srivastava, Raja Roy, Santosh Kumar, Hari Om Gupta, Devendra Singh, Jitendra Kumar Kushwaha, Abhijit Chandra, Abhinav Arun Sonkar (2013), Cholesterol and its esters as serum biomarkers in malignant Obstructive Jaundice: A single step 1H NMR metabolomic approach. Metabolomics. 9, 1181.

 

154. Deepak Gurbani, Santosh Kumar Bharti, Ashutosh Kumar, Alok K. Pandey, Godson R.E.E. Ana, Ambrish Verma, Altaf Husain Khan, Devendra K. Patel, M.K.R. Mudiam, Swatantra K. Jain, Raja Roy and Alok Dhawan (2013), Polycyclic aromatic hydrocarbons and their quinones modulate the metabolic profile and induce DNA damage in human alveolar and bronchiolar cells. International Journal of Hygiene and Environmental Health. 216, 553.

153. Bacopa Monnieri Modulate Aluminium Induced Macromolecular Changes in Rat Brain: A Magnetization Contrast Brain Imaging Study”, Sandeep Tripathi, Sanjay Annarao, Raja Roy and Abbas Ali Mahdi. Am. J of Neuroprotect. and Neuroregeneration. (2013), 5, 101.

 

152. Anil Bhatia, Santosh K. Bharti, Shri K. Tewari, Om P. Sidhu and Raja Roy (2013), Metabolic profiling for studying chemotype variations in Withania somnifera (L) Dunal fruits using GC-MS and NMR spectroscopy. Phytochemistry. 93, 105.

151. Santosh Kumar Bharti, Anu Behari, Vinay Kumar Kapoor, Niraj Kumari, Narendra Krishnani and Raja Roy (2013), Magic Angle Spinning NMR Spectroscopic Metabolic Profiling of Gall Bladder Tissues for Differentiating Malignant from Benign Disease.  Metabolomics. 9, 101.

2012

150. Neeraj Rastogi, Kalyan Mitra, Dinesh Kumar, and Raja Roy (2012), Metal Ions as Cofactors for Aggregation of Therapeutic Peptide Salmon Calcitonin.  Inorg. Chem. 51, 5642.

149. Shatakshi Srivastava, Hema Bisht, O.P. Sidhu, Ashish Srivastava, P.C. Singh, R.M. Pandey, S. K. Raj, Raja Roy and C.S. Nautiyal (2012), Changes in the metabolome and histopathology of Amaranthus hypochondriacus L. in response to Ageratum enation virus infection. Phytochemistry, 80, 8.

148. Santosh Kumar Bharti and Raja Roy (2012), Quantitative 1H NMR Spectroscopy Trends in Analytical Chemistry, 35, 5.                                

 

147. Shatakshi Srivastava, A.A. Sonkar and Raja Roy (2012), Oral Squamous Cell Carcinoma: Insights with metabonomics. Chemistry & Biology Interface. 2, 206.

146. Ritu Tyagi, Poonam Rana, Mamta Gupta, Ahmad Raza Khan,  M. Memita Devi, Deepak Bhatnagar, Raja Roy, Rajendra P. Tripathi  and Subash Khushu (2012), Urinary metabolomic phenotyping of nickel induced acute toxicity in rat: an NMR spectroscopy approach. Metabolomics. 8, 940.

145. Santosh Kumar Bharti, Virendra Jaiswal, Ujjala Ghoshal, Uday Chand Ghoshal, Sanjay S. Baijal, Raja Roy and C.L.  Khetrapal (2012), Metabolomic profiling of amoebic and pyogenic liver abscesses: An in-vitro NMR study. Metabolomics. 8, 540.

2011

144. S.K. Bharti, Anil Bhatia, S.K. Tewari, O.P. Sidhu and Raja Roy (2011), Application of HR-MAS NMR spectroscopy for studying chemotype variations of Withania somnifera (L.) Dunal. Magn.Reson.Chem. 49, 659.

143. Preeti Singh, Madan Godbole, Geeta Rao, Sanjay Annarao, Kalyan Mitra, Raja Roy, Arvind Ingle, Gaurav Agarwal and Swasti Tiwari (2011), Inhibition of autophagy stimulate molecular iodine-induced apoptosis in hormone independent breast tumors. Biochem.Biophys.Res.Comm. 415, 181.

142. O.P. Sidhu, Sanjay Annarao, Sandipan Chatterjee, Rakesh Tuli, Raja Roy and C.L. Khetrapal (2011), Metabolic alterations of Withania somnifera (L.) Dunal fruits at different developmental stages by NMR Spectroscopy. Phytochem Analysis. 22, 492.

141. V.K Singh, V. Srivastava, V. Singh, N. Rastogi, Raja Roy, A.K. Shaw, A.K. Dwivedi, R. Srivastava, B.S. Srivastava (2011), Overexpression of Rv3097c in Mycobacterium bovis BCG abolished the efficacy of BCG vaccine to protect against Mycobacterium tuberculosis infection in mice. Vaccine. 29, 4754.

 

140. Shatakshi Srivastava, Raja Roy, Vivek Gupta, Ashish Tiwari, A. N. Srivastava and A. A. Sonkar (2011), Proton HR-MAS MR Spectroscopy of Oral Squamous Cell Carcinoma Tissues: An ex-vivo study to Identify Malignancy Induced Metabolic Fingerprints. Metabolomics. 7, 278.

139. A. Mishra, S. Hutait, S.Bhuomik, N.Rastogi, Raja Roy and S.Batra (2011), Utility of Allylic Azides for the Synthesis of Fused Triazoles and Tetrazoles via Intramolecular Cycloaddition. Synthesis. 16, 2731.

2010

138. Sunil Kumar, U. C. Ghoshal, Kamaiah Jayalakshmi, Raja Roy, Asha Misra and  C. L. Khetrapal (2010), Abnormal Small Intestinal Permeability in Patients with Idiopathic Malabsorption in Tropics (Tropical Sprue) Does not Change Even After Successful Treatment. Dig. Dis. Sci. 56, 161.

137. Sandipan Chatterjee, Shatakshi Srivastava, Om Prakash Sidhu, Rajender Singh Sangwan, Raja Roy, C.L.Khetrapal and Rakesh Tuli (2010), Comprehensive metabolic fingerprinting of Withania somnifera leaf and root extracts. Phytochem. 71, 1085.

136. O.P. Sidhu, Sanjay Annarao, Uday Pathre, S. K. Snehi, S. K. Raj, Raja Roy, Rakesh Tuli and C.L.Khetrapal (2010), Metabolic and histopathological alterations of Jatropha mosaic begomovirus infected Jatropha curcas L. by HR-MAS NMR spectroscopy and Magnetic Resonance Imaging. Planta, 232, 85.

135. A.K.Verma, Preeti Khamaria, Jyoti Gupta, D.P.Singh, B.S.Joshi, Raja Roy, A.K.Mishra and Ram Pratap. (2010) Bio-transformation of FXR antagonist CDRI 80/574. ARKIVOC i. 1.

134. Shatakshi Srivastava, Raja Roy, Sudhir Singh, Praveen Kumar, Diwakar Dalela, S.N.Shankwar, Apul Gupta and A.A. Sonkar (2010), Taurine -a possible fingerprint biomarker in Non-Muscle Invasive Bladder Cancer: A pilot study by 1H NMR Spectroscopy. Cancer Biomarkers. 6, 11.

2009

133. Pratima Tripathi, Lakshmi Bala, Rajan Saxena, S.K.Yachha, Raja Roy and C.L.Khetrapal (2009), 1H NMR spectroscopic study of Blood Serum for the Assessment of Liver function in liver transplant patients. J Gastrointestin Liver Dis. 18, 329.

132. K. Jayalakshmi, U.C. Ghoshal, S. Kumar, A. Misra, Raja Roy and C. L. Khetrapal (2009), Assessment of Small Intestinal Permeability using 1H-NMR Spectroscopy. J Gastrointestin Liver Dis.18, 27.

131. Lakshmi Bala, P. Tripathi, G. Bhatt, K. Das, Raja Roy, G. Choudhuri and C. L. Khetrapal (2009), 1H and 31P NMR studies indicate reduced bile constituents in patients with biliary obstruction and infection. NMR in Biomed. 22, 220.

130. V Lakshmi, R Kumar, K Pandey, BS Joshi, Raja Roy, KP Madhusudanan, P Tiwari, AK Srivastava (2009). Structure and activities of a steroidal saponin from Chlorophytum nimonii (Grah) Dalz. Nat. Prod. Res. 23, 963.

2008

129. Divya Misra, Vivek Gupta, Abhinav A Sonkar, Usha Bajpai and Raja Roy (2008), Proton HR-MAS NMR Spectroscopic Characterization of Metabolites in Various Human Organ Tissues:  Pancreas, Brain and Liver from Trauma Cases. J. Physiol. Chem. & Phys. & Med. NMR. 40, 67.

128. RP Parti, R. Shrivastava, S Srivastava, AR Subramanian, Raja Roy, BS Srivastava, and R Srivastava.(2008), A transposon insertion mutant of Mycobacterium fortuitum attenuated in virulence and persistence in a murine infection model that is complemented by Rv3291c of Mycobacterium tuberculosis. Microb Pathog. 45, 370.

127. Santosh K Bharti, Neeraj Sinha,  Bhawani S Joshi, Sudhir K Mandal,  Raja Roy and C L Khetrapal (2008), Improved Quantification from 1H-NMR Spectra Using Reduced Repetition Times. Metabolomics. 4, 367.

126. Abhijeet Deb Roy, K. Jayalakshmi, Somnath Dasgupta, Raja Roy and B. Mukhopadhyay (2008), Real time HR-MAS NMR: Application in reaction optimization, mechanism elucidation and kinetic analysis for heterogeneous reagent catalyzed small molecule chemistry. Magn.Reson.Chem. 46, 1119.

125. Abbas A. Mahdi, Sanjay Annarao, Sandeep Tripathi, Akbar Nawab, Farzana Mahdi, Mahdi Hasan, Raja Roy and C.L. Khetrapal (2008), Correlation of Age-Related Metabonomic Changes in 1H NMR Serum and Urine Profiles of Rats with Cognitive Function. The Open Magnetic Resonance Journal.  1, 12

124. Sanjay Annarao, O.P. Sidhu , Raja Roy, Rakesh Tuli and C.L. Khetrapal (2008), Lipid profiling of developing Jatropha curcas L. seeds using 1H-NMR Spectroscopy. Bioresource technol. 99, 9032

123. Sandeep Tripathi, Somashekar B. S, Abbas Ali Mahdi, Ashish Gupta, Farzana Mahdi, Mahdi Hasan, Raja Roy and C. L. Khetrapal (2008), Aluminum Mediated Metabolic Changes in Rat Serum and Urine: A Proton Nuclear Magnetic Resonance Study. J.Biochem. Molecular Toxicology. 22, 119.

122. Laxmi Bala, A Sharma, R.K. Yellapa, Raja Roy, Gour Choudhuri and C.L. Khetrapal. (2008), 1H NMR spectroscopy of ascitic fluid: discrimination between malignant and benign ascites and comparison of the results with conventional methods. NMR in Biomed. 21, 606.

121. Arunachalam Subramanian, Bhawani Shankar Joshi, Abhijeet Deb Roy, Raja Roy, Vivek Gupta and Ramandeep S. Dang (2008), NMR Spectroscopic Identification of Cholesterol Esters, Plasmalogen and Phenolic Glycolipids as Finger-Print Markers of Human Intracranial Tuberculomas. NMR in Biomed.  21, 272.

2007

120. Ruchika Chakrabarty, Jyoti Rao, Aparna Anand, Abhijeet Deb Roy, Raja Roy, G. Shankar, P.R. Dua and Anil K. Saxena (2007), Rational design, synthesis and evaluation of (6aR*,11bS*)-1-(4-fluorophenyl)-4-{7-[4-(4-fluorophenyl)-4-oxobutyl]1,2,3,4,6,6a,7,11b,12,12a(RS)-decahydropyrazino[2′,1′:6,1]pyrido[3,4-b]indol-2-yl}-butan-1-one as a potential neuroleptic agent. Bioorg Med Chem.  15, 7361.

119. A.K. Dwivedi, V.L. Sharma, N. Kumaria, S.T. Kiran Kumar, P.K. Srivastava, A.H. Ansari, J.P. Maikhuri, G. Gupta, J.D. Dhar, Raja Roy, B.S. Joshi, P.K. Shukla, M.Kumar, S.Singh. (2007), Synthesis of disulfide esters of dialkylaminocarbothioic acid as potent, non-detergent spermicidal agents. Bioorg Med Chem. 15, 6642.

118. Ramendra Pratap, Abhijeet Deb Roy, Shom Prakash Kushwaha, Atul Goel, Raja Roy and Vishnu Ji Ram (2007), Guanidine and amidine mediated synthesis of bridgehead triazaphenalenes, pyrimidines and pyridines through domino reactions. Tet. Lett. 48, 5845

117. Aparna Anand, Abhijeet Deb Roy, Ruchika Chakrabarty, Anil K. Saxena and Raja Roy (2007), Investigation of the barrier to the rotation of carbamate and amide C-N bonds in antidepressant (6aR*,11bS*)-7-[carbobenzyloxy-L-alanyl]-2-[(4-methylphenyl)sulphonyl]-1,2,3,4,6,6a,7,11b,2,12a(S)decahydropyrazino [2',1':6,1]pyrido[3,4-b] indole by dynamic NMR and molecular mechanics. Tetrahedron. 63, 5236.

116. Ramendra Pratap, Abhijeet Deb Roy, Raja Roy and Vishnu Ji Ram (2007), A novel synthesis of aryl tethered imidazo[4,5-b]pyrazin-2-ones through in situ ring construction and contraction. Tet. Lett. 48, 1281.

Patents Details

 

1.    Novel spermicidal and antifungal agents.

Anil Kumar Dwivedi, Vishnulal Sharma, Niharika Kumaria, Kiran Kumar, Gopal Gupta, Jagdamba Prasad Maikhuri Janak Dulari Dhar, Pradeep Kumar, Abdul Haq Ansari, Praveen Kumar Shukla, Manish Kumar, Raja Roy, Kunnath Padmanabhan Madhusudhanan, Ram Chandra Gupta. Indian Patent No. 245815, 2001.

 

2.    Isolation of tigogenin pentaglycoside from Chlorophytum nimonii. 

Lakshmi Vijay, Kartikay Pandey, Raja Roy, Bhawani Shankar Joshi, Padmanabhan Madhusudanan Kunnath, Ramesh Chandra, Arvind Kumar Srivastava, Deepak Raina, Anil Kumar Rastogi. US Patent No. 7160866, 2009.

ents:

 

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